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Again, it must be noted that therapy will only help the individual if they admit they do have a problem.​ Maintaining a relationship of any kind with a person suffering from compulsive lying syndrome can be complicated.

People with the disorder are not able to control their lies and experience no guilt regardless of how the lies may affect themselves and others.

The lack of guilt is frequently the result of the fact that the individual becomes so caught up in the lie that they are telling, they begin to believe it themselves.

There has been research completed that indicates it is the result of neurological imbalance, particularly in the frontal lobe.

A study published in the British Journal of Psychiatry reported that pathological liars have an increase in the amount of white matter in the brain predisposing them to the condition.

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